Beilstein J. Org. Chem.2015,11, 358–362, doi:10.3762/bjoc.11.41
obtainment of valuable 3-chloropropyl cinnamates (Table 2, entries 11–13) with good to excellent yields. Haloalkyl cinnamates are important building blocks in the synthesis of nitric oxide-donor hybriddrugs for the treatment of cardiovascular disease and cancer [14][15][16][17]. Previously, haloalkyl
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Graphical Abstract
Scheme 1:
Arylation of methyl acrylate (1a) with arenediazonium tosylate 2a.
Beilstein J. Org. Chem.2013,9, 15–25, doi:10.3762/bjoc.9.3
of this new class of inhibitors.
Keywords: activity-based probes; Chagas’ disease; cruzain; CYP51; 14-α-demethylase; hybriddrugs; Trypanosoma cruzi; Introduction
The kinetoplastid protozoan Trypanosoma cruzi is the causative agent of Chagas’ disease, a leading cause of heart failure in endemic
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Graphical Abstract
Figure 1:
Chemical structures of vinylsulfone-based cruzain inhibitors 1–4, known TcCYP51 inhibitor 5, dihydr...